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Anticholinergic drugs neuroleptic drugs concomitant use of anticholinergic drugs including diphenhydramine, loratadine, oxybutynin, solifenacin, and olanzapine with tricyclic antidepressant like amitriptyline result in increased risk of side effects.

The information below for olanzapine is derived from a clinical trial database for olanzapine consisting of 8661 adult patients with approximately 4165 patient-years of exposure to oral olanzapine and 722 patients with exposure to intramuscular olanzapine for injection.

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Transaminase elevations in placebo controlled studies, clinically significant alt sgpt elevations 3 times the upper limit of the normal range were observed in 2 6 243 of patients exposed to olanzapine compared to none 0 115 of the placebo patients.

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In addition, co-administration of olanzapine with asenapine may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures.

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In a second 12-month recurrence prevention study in manic episode patients who achieved remission with a combination of olanzapine and lithium and were then randomised to olanzapine or lithium alone, olanzapine was statistically non-inferior to lithium on the primary endpoint of bipolar recurrence olanzapine 30.

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olanzapine should be used cautiously in patients with a history of seizures or with conditions that potentially lower the seizure threshold, e.

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